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Smallpox Vaccine

The vaccine itself is not without dangers. Approximately 14-52 out of every 1,000,000 vaccinated will develop a life-threatening condition, of which 1-2 will be expected to die. For this reason, an intensive pre-screening program is being implemented to remove those individuals most likely to suffer adverse reactions from the voluntary phases of the vaccination plan. Contraindications must be considered not only for the vaccine, but also for those household members that meet any one of the following criteria:

  • Expectant mothers.
  • Persons with eczema or atopic dermatitis, characterized by an itchy, red, scaly rash that lasts more than two weeks and often appears intermittently.
  • Persons being treated for cancer.
  • Persons who are HIV-positive.
  • Persons who have had an organ transplant.
  • Persons who have had a previous reaction to the vaccine or its contents.
  • Persons who have a moderate or severe short-term illness at the time of vaccination.
  • Persons under the age of one.

The vaccine used to provide protection against smallpox is made from the live vaccinia virus, NOT the smallpox virus. Thus, an individual that has a disseminated reaction cannot spread the smallpox virus, but may be able to spread vaccinia to those that have had direct contact with the vaccination site. For this reason, specific precautions must be taken for the vaccination site, including maintaining a porous covering that will reduce the risk of transmitting vaccinia while allowing for proper healing of the vaccination scar.

For more information:


Emergency Preparedness Program
Boulder County Public Health
3450 Broadway, Boulder, CO 80304
(303) 413-7500

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